From: RBHOGGAN@cbe.ab.ca
Date: Tue, 04 Jun 1996 00:11:21 -0700 (MST)
Subject: Depression

There is a tremendous volume of information that ties depressive illness 
to gluten intolerance.

In 1976, Dr. Richard Mackarness published his book "NOT ALL IN THE MIND"
through Thorsons of Hammersmith, London, and San Francisco. He repeatedly 
demonstrates that food allergies, especially in gluten allergies or 
intolerance, behavioural and psychiatric symptoms are common. 

Cooke & Holmes, in their book, "COELIAC DISEASE" published by Churchill 
Livingstone, New York, 1984, they repeatedly cite depressive illness as 
THE MOST COMMON symptom of gluten intolerance. They also cite a study 
that demonstrated that newly diagnosed celiacs recover from their 
depressions much more quickly when their diets are supplemented with 
vitamin B6. Of course, malabsorption of fat soluble vitamins is legion in
gluten intolerance, but all vitamin absorption is a problem. The jejunal 
microvilli are damaged such that they do not absorb fats (and therefore 
fat soluble vitamins) very well, but B6, B12, and folic acid deficiencies 
that virtually always accompany gluten intolerance, are all involved in 
neurotransmission. 

Do not be misled. Because fats can be made from other foods, the 
malabsorption associated with gluten intolerance need not suggest an 
underweight condition in our calorie rich diets. 

Dr Kozlowska, in her article "Evaluation of Mental Status of Children 
with Malabsorption Syndrome After Long-Term Treatment" published in 
"PSYCHIATRIA POLSKA" 25/2 Mar/Apr. 1991, identified fully 71% of the 
children they studied as having psychiatric disturbances. 

In "PRINCIPLES OF ANATOMY AND PHYSIOLOGY" 6th ed. by Tortora & 
Anagnostakos, Harper & Row, New York, 1990, the authors make the very 
clear statement:
"you will also learn that certain disorders such as Parkinson's disease, 
Alzheimer's disease, depression, anxiety, and schizophrenia involve 
improperly functioning neurotransmitters."

Opioids, of course, will compete for endorphin receptors in the synapses, 
thus altering the neurotransmission at synapses where the opioids have 
attached.

Zioudrou et. al. in "Opioid Peptides Derived From Food Proteins" in 
"JOURNAL OF BIOLOGICAL CHEMISTRY" vol. 254, no. 7, page 2446, April 10, 
1979, clearly demonstrated that pepsin digests of wheat can form these 
opioids in the gut. 

Husby, et. al. in "Passage of Undegraded Dietary Antigen into the Blood 
of Healthy Adults" in "SCAND. JOURNAL OF IMMUNOLOGY" 22, 1985, 
demonstrate how these opioids pass through the intestinal wall, and into 
the bloodstream. 

Paul H. Black, in "Psychoneuroimmunology: Brain and Immunity" in 
SCIENTIFIC AMERICAN SCIENCE & MEDICINE, vol. 2, issue 6, p. 16, Nov-Dec, 
1995, has shown how opioids may enter the brain through the HPA axis, 
thereby bypassing the blood brain barrier. 

These are just two possible explanations for depression in celiac 
disease. There are many more. The point is that such depressions need to 
be treated with a gluten-free diet, and vitamin supplementation, where 
possible intravenously, because of poor absorption. 

 
I am not a doctor. I am just trying offer an alternative. Please consult 
a physician for advice pertinent to your situation. For instance, if her 
health permits, you might have her fast for three days. If there is an 
improvement, then the problem is quite likely the result of something she 
is eating. A physician would be able to determine if she is fit enough to 
safely undertake such a fast.  

I hope that is helpful,

Ron Hoggan

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Date: Tue, 09 Jul 1996 21:36:55 -0700 (MST)
From: "Ronald Hoggan, Queen Elizabeth High School" 
Subject: Re: more on Depression and Gluten on autism list

Hi Don,
You might point the discussion at:
Saelid G, et. al. "Peptide-Containing Fractions in Depression" _Biol 
Psychiatry_ 1985;20: 245-256

This is a report that demonstrates a variation in urinary peptides in
psychotic depression. Nonetheless, it is difficult to argue that opioids
cannot be involved in depression, when this group reports what appear
to be the same peptides in the urine of depressed people, in greater 
quantity than normal. Bear in mind that psychotic depression often 
includes hallucinations.......which brings us back to LSD....
for what its worth, they make the point that the peptides can not be
clearly connected to diet. In fact, they seem to be of the opinion 
that the peptides are endogenous, and a peptidase insufficiency is at the
root of the problem. But isn't it fairly possible that exogenous peptides
with opioid activity, assuming increased intestinal permeability, might
offer an explanation for this? I think so. 

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Date: Thu, 11 Jul 1996 21:21:48 -0700 (MST)
From: "Ronald Hoggan, Queen Elizabeth High School" 

BTW  here is a direct quote:
"Abnormal plasma amino acid concentrations have been found in children with 
celiac disease and could be implicated in mood and behavioural disorders."

I'm sure you're aware that peptides are chains of amino acids. 

Goggins & Kelleher "Celiac Disease and Other nutrient Related Injuries to 
the Gastrointestinal Tract" _The American Journal of Gastroenterology_ 
1994; 89(8): S2 -S13.

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