There are a few reports on celiac associated leukemia. I have appended five
citations, two of which are accompanied by abstracts. Although the
association does not appear to be common, it is difficult to tell if that
is due to the low level of suspicion of celiac disease in general, or if it
is due to a rare association. The findings of Fundia et al. (6) suggest
that the association may be more common. Please not that Molitor et al. (1)
talk about an " intriguing association of celiac disease with T-LGL
leukemia." It may also be that the report by Chapman et al.(2) may reflect
both the Fundia et al.(6) findings, as well as suggesting an indirect
connection between pernicious anemia, which is often found in celiac
disease and the high incidence of leukemia in pernicious anemia (7). 


1. Molitor JL, Saint-Louis J, Louvet C, Vachon A, Vincent L, Beaulieu R
[Large granular T-cell lymphocytic leukemia disclosed by bilateral uveitis:
association with celiac disease].
Rev Med Interne 1997;18(3):237-9 

A 70-year-old woman presented with bilateral anterior uveitis. She was on a
gluten-free diet because of a celiac disease which had been diagnosed 3
months before. An anterior chamber aspirate contained a majority of large
granular lymphocytes (LGL). The investigation of a chronic neutropenia led
to the diagnosis of an otherwise typical T-LGL leukemia. This seems to be
the first report of a CD3+ CD4- CD8+ T-LGL leukemia causing anterior
uveitis through infiltration of leukemic cells, and the second report of an
intriguing association of celiac disease with T-LGL leukemia. 


2.    Chapman CS, Mitchell VE, Alexander CP, Potter AM
Loss of Philadelphia chromosome in chronic myeloid leukaemia associated
with coeliac disease and splenic atrophy.
Br Med J (Clin Res Ed) 1988 Jun 4;296(6636):1574-5 


3.    Trejdosiewicz LK, Malizia G, Oakes J, Losowsky MS, Janossy G
Expression of the common acute lymphoblastic leukaemia antigen (CALLA
gp100) in the brush border of normal jejunum and jejunum of patients with
coeliac disease.J Clin Pathol 1985 Sep;38(9):1002-6 

Expression of the gp100 common acute lymphoblastic leukaemia antigen
(CALLA) was studied in the mucosa of the gut by means of indirect
immunofluorescence on cryostat tissue sections with a panel of eight
monoclonal antibodies to common acute lymphoblastic leukaemia antigen
(anti-CALLA antibodies) and two antibodies to non-CALLA leukaemic antigens.
Expression of CALLA was absent from normal stomach epithelium, adult and
fetal colonic epithelium of normal histology, and colonic epithelium from
patients with Crohn's disease or ulcerative colitis. By contrast, all eight
anti-CALLA antibodies gave a characteristic reaction in normal adult and
fetal small bowel mucosa, with specific localisation to the entire brush
border of jejunal epithelium. Whereas seven of these antibodies reacted
both with normal jejunal epithelium and with the damaged epithelium of
patients with coeliac disease, antibody RFAL-2 reacted strongly only with
histologically normal small bowel but more weakly in patients with coeliac
disease to a degree related to the amount of histological abnormality.
Expression of the moeity like CALLA identified with RFAL-2 was strongest in
crypt epithelium and proportionally diminished along the villi according to
the amount of histological damage in coeliac disease, being essentially
absent in patients with "subtotal villous atrophy." 


4.   Re G, Zaccaria A, Calabrese L, Gobbi M, Lauria F, Cavalli G
Hairy-cell leukemia complicating coeliac disease: report of a case and
discussion of possible pathogenetic mechanisms.
Acta Haematol 1984;71(2):130-4 

10-28% of the patients with chronic coeliac disease develop a second
malignancy, such as non-Hodgkin's lymphomas, particularly of the
histiocytic type, and adenocarcinomas. The second tumor may arise in the
intestinal tract or in other organs. We describe here a patient who
developed a tartrate-resistant, acid phosphatase-positive, hairy-cell
leukemia after a history of chronic coeliac disease. In the literature, no
similar case has been described as yet. 


5. Gupte SP, et al.    
Acute myeloid leukemia in a girl with celiac disease. 
Am J Dig Dis. 1971 Oct;16(10):939-41. 


6. Fundia A, Gomez JC, Maurino E, Boerr L, Bai JC, Larripa I, Slavutsky I
Chromosome instability in untreated adult celiac disease patients.
Acta Paediatr Suppl 1996 May;412:82-4 

Spontaneous chromosome aberrations (CAs) and induced fragile sites (FSs)
were analysed in 12 untreated adult coeliac disease (CD) patients and 8
healthy controls. Blood lymphocytes from each individual were cultured for
72 h at 37 degrees C in F-10 medium with 5% fetal calf serum and 0.1 ml
phytohemagglutinine. FSs were induced by FudR (10 micrograms/ml, 24 h
before harvesting) and caffeine (2.2 mM. 6 h before harvest). Spontaneous
CAs and FSs were analysed on 30-50 Giemsa-stained and G-banded metaphases.
The mean frequencies of spontaneous CAs (abnormal cells, gaps/cell and
breaks/cell) of CD patients (0.24 +/- 0.02, 0.21 +/- 0.02 and 0.13 +/-
0.02, respectively) were significantly higher than those of controls (0.04
+/- 0.01, 0.02 +/- 0.01 and 0.02 +/- 0.01, respectively) (p < 0.001).
Fourteen spontaneous CAs and 5 FSs specific for CD patients presented a
strong coincidence (70%) with bands involved in T- and B-cell malignant
lymphoma rearrangements. These findings suggest that CD has chromosome
instability affecting specific points that could be related to the high
prevalence of malignancies in this disorder. 

   
7. Hsing AW, Hansson LE, McLaughlin JK, Nyren O, Blot WJ, Ekbom A, Fraumeni
JF Jr
Pernicious anemia and subsequent cancer. A population-based cohort study.
 Cancer 1993 Feb 1;71(3):745-50