Date: Thu, 31 Jul 1997 11:46:59 GMT
From: (Ron Hoggan)
Subject: Re: nephotic syndrome

On 29 Jul 1997 03:33:06 GMT, "Stacy Jedynak"  wrote:

>Our 4 year old son was just diagnosed with nephrotic syndrome and has been
>on steroids for just over a week. We are very concerned and need more
>My father also had a dose of this a few years back when he was in his late
>sixties. The prednisone seened to have cleared it up without any
>recurrance. Again. no specific cause was every found, even after a biopsy.

Hi Stacy, 
Has anyone in your family ever tested positive for celiac disease? I will
append a few references that indicate that kidney problems can be
associated with celiac disease. Of course, it could be unrelated, but I
always wonder about celiac disease when I hear about kidney problems.

I know that # 20 is very old, but if you look at the age when it all began,
it is difficult not to leap to some conclusions. Perhaps I am very wrong in
even suggesting the possibility. I hope you are not offended by my
comments, when you only asked to hear from others who had experienced the
same thing. 

1. Rostoker G, "IgA mesangial nephritis, IgA antigliadin antibodies, and
coeliac disease" _Lancet_ 1990; 336(8718): 824-825  

2. Woodroffe AJ, "Mesangial IgA nephritis" _Springer Semin Immunopathol_
1982; 5(3): 321-332 
3. Mignot E, "DQCAR microsatellite polymorphisms in three selected HLA
class II-associated diseases" _Tissue Antigens_ 1995; 46(4): 299-304  

4. Woodrow G, "A case of IgA nephropathy with coeliac disease responding to
a gluten-free diet" _Nephrol Dial Transplant_ 1993; 8(12): 1382-1383 

5. Laurent J, "An increase in circulating IgA antibodies to gliadin in IgA
mesangial glomerulonephritis" _Am J Nephrol_ 1987; 7(3): 178-183  

6. Scholey J, "Celiac sprue-associated immune complex glomerulonephritis"
_J Clin Gastroenterol_ 1986; 8(2): 181-183  

7. Gaboardi F, "Dermatitis herpetiformis and nephrotic syndrome" _Clin
Nephrol_ 1983; 20(1): 49-51  

8. Farthing MJ, "Radiologic features of the jejunum in hypoalbuminemia" 
_AJR Am J Roentgenol_ 1981; 136(5): 883-886  

9. Amore A, "Functional consequences of the binding of gliadin to cultured
rat mesangial cells: bridging immunoglobulin A to cells and modulation of
eicosanoid synthesis and altered cytokine production" _Am J Kidney Dis_
1994; 23(2): 290-301 

10. Falchuk KR, "The intestinal and liver complications of diabetes
mellitus" _Adv Intern Med_ 1993; 38: 269-286 

11. Gans RO, "The occurrence of IgA-nephropathy in patients with diabetes
mellitus may not be coincidental: a report of five cases" _Am J Kidney Dis_
1992; 20(3): 255-260 

12. Coppo R, "Dietary antigens and primary immunoglobulin A nephropathy"
_J Am Soc Nephrol_ 1992; 2(10): S173-S180 

13. Sategna-Guidetti C, "Do IgA antigliadin and IgA antiendomysium
antibodies show there is latent coeliac disease in primary IgA nephropathy?
_Gut_ 1992; 33(4): 476-478 

14. Mainguet P, "Celiac disease in adults: clinical aspects--role of
endoscopy" _Acta Gastroenterol Belg_ 1992;  55(2): 181-189  

15. Savige JA, "Circulating anti-glomerular basement membrane antibodies in
coeliac disease and epidermolysis bullosa acquisita" _Aust N Z J Med_ 1991;
21(6): 867-870

16. Niven MJ, "T-cell receptor beta-subunit gene polymorphism and
autoimmune disease" _Hum Immunol_  1990; 27(4): 360-367  

17. Kumar V, "Are immunological markers of gluten-sensitive enteropathy
detectable in IgA nephropathy?" _Lancet_ 1988; 2(8623): 1307 

18. Sacks SH, "Functional and biochemical subtypes of the haplotype HLA-DR3
in patients with celiac disease or idiopathic membranous nephropathy" _Hum
Immunol_ 1987; 20(2): 175-187  

19. Helin H, "IgA nephropathy associated with celiac disease and dermatitis
herpetiformis" _Arch Pathol Lab Med_ 1983; 107(6): 324-327  

20. Codaccioni JL, "Unusual development during a 1-year period of multiple
complications (steatorrhea, nephropathy, statural retardation, cerebral
accidents) in a 15-year-old child diabetic since the age of 4" _Diabete_
1968; 16(2): 146-152 

Best Wishes, 
Ron Hoggan