Newsgroup: misc.kids.health
Date: Thu, 31 Jul 1997
From: Ron Hoggan
Subject: Re: nephotic syndrome

On 29 Jul 1997, Stacy Jedynak (jazzer at nycap.rr.com) wrote:

>Our 4 year old son was just diagnosed with nephrotic syndrome and has been
>on steroids for just over a week. We are very concerned and need more
>information.
>
>My father also had a dose of this a few years back when he was in his late
>sixties. The prednisone seened to have cleared it up without any
>recurrance. Again. no specific cause was every found, even after a biopsy.

Hi Stacy,
Has anyone in your family ever tested positive for celiac disease? I will append a few references that indicate that kidney problems can be associated with celiac disease. Of course, it could be unrelated, but I always wonder about celiac disease when I hear about kidney problems.

I know that # 20 is very old, but if you look at the age when it all began, it is difficult not to leap to some conclusions. Perhaps I am very wrong in even suggesting the possibility. I hope you are not offended by my comments, when you only asked to hear from others who had experienced the same thing.

1. Rostoker G, "IgA mesangial nephritis, IgA antigliadin antibodies, and coeliac disease" _Lancet_ 1990; 336(8718): 824-825
2. Woodroffe AJ, "Mesangial IgA nephritis" _Springer Semin Immunopathol_ 1982; 5(3): 321-332
3. Mignot E, "DQCAR microsatellite polymorphisms in three selected HLA class II-associated diseases" _Tissue Antigens_ 1995; 46(4): 299-304
4. Woodrow G, "A case of IgA nephropathy with coeliac disease responding to a gluten-free diet" _Nephrol Dial Transplant_ 1993; 8(12): 1382-1383
5. Laurent J, "An increase in circulating IgA antibodies to gliadin in IgA mesangial glomerulonephritis" _Am J Nephrol_ 1987; 7(3): 178-183
6. Scholey J, "Celiac sprue-associated immune complex glomerulonephritis" _J Clin Gastroenterol_ 1986; 8(2): 181-183
7. Gaboardi F, "Dermatitis herpetiformis and nephrotic syndrome" _Clin Nephrol_ 1983; 20(1): 49-51
8. Farthing MJ, "Radiologic features of the jejunum in hypoalbuminemia" _AJR Am J Roentgenol_ 1981; 136(5): 883-886
9. Amore A, "Functional consequences of the binding of gliadin to cultured rat mesangial cells: bridging immunoglobulin A to cells and modulation of eicosanoid synthesis and altered cytokine production" _Am J Kidney Dis_ 1994; 23(2): 290-301
10. Falchuk KR, "The intestinal and liver complications of diabetes mellitus" _Adv Intern Med_ 1993; 38: 269-286
11. Gans RO, "The occurrence of IgA-nephropathy in patients with diabetes mellitus may not be coincidental: a report of five cases" _Am J Kidney Dis_ 1992; 20(3): 255-260
12. Coppo R, "Dietary antigens and primary immunoglobulin A nephropathy" _J Am Soc Nephrol_ 1992; 2(10): S173-S180
13. Sategna-Guidetti C, "Do IgA antigliadin and IgA antiendomysium antibodies show there is latent coeliac disease in primary IgA nephropathy? _Gut_ 1992; 33(4): 476-478
14. Mainguet P, "Celiac disease in adults: clinical aspects--role of endoscopy" _Acta Gastroenterol Belg_ 1992; 55(2): 181-189
15. Savige JA, "Circulating anti-glomerular basement membrane antibodies in coeliac disease and epidermolysis bullosa acquisita" _Aust N Z J Med_ 1991; 21(6): 867-870
16. Niven MJ, "T-cell receptor beta-subunit gene polymorphism and autoimmune disease" _Hum Immunol_ 1990; 27(4): 360-367
17. Kumar V, "Are immunological markers of gluten-sensitive enteropathy detectable in IgA nephropathy?" _Lancet_ 1988; 2(8623): 1307
18. Sacks SH, "Functional and biochemical subtypes of the haplotype HLA-DR3 in patients with celiac disease or idiopathic membranous nephropathy" _Hum Immunol_ 1987; 20(2): 175-187
19. Helin H, "IgA nephropathy associated with celiac disease and dermatitis herpetiformis" _Arch Pathol Lab Med_ 1983; 107(6): 324-327
20. Codaccioni JL, "Unusual development during a 1-year period of multiple complications (steatorrhea, nephropathy, statural retardation, cerebral accidents) in a 15-year-old child diabetic since the age of 4" _Diabete_ 1968; 16(2): 146-152