From: RBHOGGAN@cbe.ab.ca
Date: Tue, 04 Jun 1996 00:37:22 -0700 (MST)
Subject: PMS AND SEROTONIN

Hi Don, 

There is a whole pile of conflicting information out there about 
serotonin. In "PRINCIPLES OF ANATOMY AND PHYSIOLOGY" 6 th ed. by Tortora 
& Anagnostakos, pub. Harper & Row, 1990. On page 409,  serotonin is 
described as follows: 
"Concentrated in neurons in the raphe nucleus in the brain stem; leads to 
excitation and may be involved in inducing sleep, sensory perception, 
temperature regulation, and control of mood. 

It is, of course, a neurotransmitter. 

In the same text, on page 350, "acidosis" is defined as: "a decrease in ph 
below 7.35, results in a depressive progression of neuronal activity that 
can produce apathy, weakness, and a comatose state. 

Largilliere, et. al. in  "Pseudo-glutaric aciduria type II in a patient 
with celiac disease" page 504, "JOURNAL OF PEDIATRICS" March, 1993, 
identify a deficiency in essential fatty acid deficiency in a child with 
celiac disease showed test results that indicated glutaric aciduria type 
II, without the clinical history to go with it. Further exploration 
revealed serum antibodies, which led, ultimately, to a diagnosis of 
gluten intolerance. 

This may all seem a little random, but my point is that mood control is, 
in part, a function of serotonin, which can be effected by gluten, in 
susceptible individuals. 

Just prior to menses, women experience increased intestinal permeability.
(I'll have to look up the reference on that, but it struck me as so odd, 
that it stuck in my mind. I wish the source had been as memorable. )

Serotonin levels might also be effected by the exogenous opioids during  
this period of increased intestinal permeability. 

In either case, it would seem advisable to try going gluten-free, and 
milk free, for 3 days before menses. It might eliminate PMS. I would sure
be interested in hearing if it works. 

I am not a doctor. 

I hope that is helpful,

Ron Hoggan